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In another small study involving 15 patients receiving hemodialysis (where blood is pumped out of the body to an artificial kidney machine), they were found to have gastrointestinal symptoms, including constipation (likely due to restrictions in their water intake required as part of their therapy), as well as carnitine deficiency

Folic acid should be used with care in the presence of peptic ulcer disease, regional enteritis, and ulcerative colitis

These persistent agents induce chronic inflammation and oxidative stress, identified as the primary KEs (144)

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Alternatively functional redundancy might have prevented us from observing any phenotype for single mutants

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